Structure of PDB 5wp6 Chain C Binding Site BS01

Receptor Information
>5wp6 Chain C (length=977) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQSWIPKIFKKKTCHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAA
VYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGA
WIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLI
NPKGSFPARYRWRGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESY
ISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGG
AADCLAETLEDTRQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVY
SSEDGSEEFETIVLKALVKACGSYLDELRLAVAWNRVDIAQSELFRGDIQ
WRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPS
NSLIRNLLDQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLL
RVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRC
PLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLA
FFCPPLIYTRLITFRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVL
LVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGSLASGGPGPGHASLS
QRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFT
VRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLR
PRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHP
PGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGN
SDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQALEHFRVYLSKE
AERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIR
EYEQRLKVLEREVQQCSRVLGWVAEAL
Ligand information
Ligand IDDVT
InChIInChI=1S/28O.10V/q;;;;;;;;;;;;;;8*-1;4*+1;2*+4;10*-1
InChIKeyWOYKCMUEHQAMTC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
[O-][V-]1234O[V-]567([O-])O[V-]89([O-])(O1)[O+]%10[V-]%11%12%13([O-])O[V-]%14%15%16([O-])O[V-]%17%18([O-])(O%11)O[V-]%19%20([O-])(O%14)[O+]%21[V-]%22([O-])(O2)(O5)[O+]%19[V-]%23(O%17)([O+4]6)([O+]8%12)[O]379%22[V-]%10%21(O4)(O%15)[O+4]%13%16%18%20%23
[O-][V-]1234O[V-]567(O1891[V-]%10(O2)(O5)([O+]2[V-]858(O3)O[V-]3%11%12([O+4]55%13%14[V-]22(O3)([O+]%10[V-]953([O+4]6)O[V-]%13(O%11)(O2)(O[V-]%142(O%12)([O+]8[V-]1([O+]32)(O4)(O7)[O-])[O-])[O-])[O-])[O-])[O-])[O-]
FormulaO28 V10
NameDECAVANADATE
ChEMBL
DrugBank
ZINC
PDB chain5wp6 Chain C Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wp6 Electron cryo-microscopy structure of a human TRPM4 channel.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R1141 R1147
Binding residue
(residue number reindexed from 1)		R925 R931
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0010460 positive regulation of heart rate
GO:0016925 protein sumoylation
GO:0019722 calcium-mediated signaling
GO:0030502 negative regulation of bone mineralization
GO:0034220 monoatomic ion transmembrane transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098662 inorganic cation transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:1903949 positive regulation of atrial cardiac muscle cell action potential
GO:1904179 positive regulation of adipose tissue development
GO:1904199 positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5wp6, PDBe:5wp6, PDBj:5wp6
PDBsum5wp6
PubMed29211723
UniProtQ8TD43|TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (Gene Name=TRPM4)

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