Structure of PDB 5wch Chain C Binding Site BS01

Receptor Information

>5wch Chain C (length=342) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGTEDRAAYNIGVL
RHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLV
DSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDI
RNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLA
IQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGSTKYRLV
GVLVHSGQASGGHYYSYIIQRRWYKFDDGDVTECKMDDDEEMKNQCFGGE
YMGEVFDHKRMSYRRQKRWWNAYILFYERMDTQDDELIRYIS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5wch Chain C Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5wch Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	C1727 H1729 C1771 C1774
Binding residue (residue number reindexed from 1)	C133 H135 C177 C180
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.19.12: ubiquitinyl hydrolase 1.

Gene Ontology

	Molecular Function
GO:0004843	cysteine-type deubiquitinase activity

	Biological Process
GO:0016579	protein deubiquitination

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Molecular Function

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Biological Process

External links

PDB	RCSB:5wch, PDBe:5wch, PDBj:5wch
PDBsum	5wch
PubMed	30914461
UniProt	Q93008\|USP9X_HUMAN Ubiquitin carboxyl-terminal hydrolase 9X (Gene Name=USP9X)

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