Structure of PDB 5w6q Chain C Binding Site BS01

Receptor Information
>5w6q Chain C (length=521) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLK
EARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGG
EWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHVEA
TGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFD
ELGLPAIGKTEKTGKRSTSAAVLEALREAHAIVEKILQYRELTKLKSTYI
DPLPELIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRR
AFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKT
LEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADL
MKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGV
YPLAVPLEVEVGIGEDWLSAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5w6q Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		R487 T506 K508 T509 S513 T514 S515 A516 R536 K540 Y545 R573 Q582 N583 I584 P585 R587 V783 H784 D785
Binding residue
(residue number reindexed from 1)		R191 T210 K212 T213 S217 T218 S219 A220 R240 K244 Y249 R277 Q286 N287 I288 P289 R291 V473 H474 D475
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5w6q, PDBe:5w6q, PDBj:5w6q
PDBsum5w6q
PubMed29986111
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

[Back to BioLiP]