Structure of PDB 5w5i Chain C Binding Site BS01

Receptor Information
>5w5i Chain C (length=436) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLSVGIHNLLAYVK
HLKGQNEEALKSLKEAENLVRSLVTWGNFAWMYYHMGRLAEAQTYLDKVE
NICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDP
ENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVL
LALKLQDEGQEAEGEKYIEEALANMTYVFRYAAKFYRRKGSVDKALELLK
KALQETPTSVLLHHQIGLCYKAQMIQIKEANREKLDKMIRSAIFHFESAV
EKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFH
YGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRKLRRK
ALDLESLSLLGFVYKLEGNMNEALEYYERALRLAAD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5w5i Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R38 K151 Y157 R187 G190 F191 L193 A194 Y252 R255 Y256 K259 R262 L286 H289 Q290 L293 K336 F339 V341 D345 V372 D379
Binding residue
(residue number reindexed from 1)		R30 K129 Y135 R165 G168 F169 L171 A172 Y227 R230 Y231 K234 R237 L261 H264 Q265 L268 K303 F306 V308 D312 V339 D346
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0009615 response to virus
GO:0019060 intracellular transport of viral protein in host cell
GO:0032091 negative regulation of protein binding
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051097 negative regulation of helicase activity
GO:0051607 defense response to virus
GO:0051707 response to other organism
GO:0071357 cellular response to type I interferon
GO:0071360 cellular response to exogenous dsRNA
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043657 host cell

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5w5i, PDBe:5w5i, PDBj:5w5i
PDBsum5w5i
PubMed
UniProtP09914|IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (Gene Name=IFIT1)

[Back to BioLiP]