Structure of PDB 5w5h Chain C Binding Site BS01

Receptor Information
>5w5h Chain C (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLL
AYVKHLKGQNEEALKSLKEAENLMQEANVRSLVTWGNFAWMYYHMGRLAE
AQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKAC
FEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLN
PDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRR
KGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEREKLDKMIR
SAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVV
EETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLK
KLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAAD
Ligand information
Receptor-Ligand Complex Structure
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PDB5w5h Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
Resolution2.79 Å
Binding residue
(original residue number in PDB)		R38 Q42 T48 W147 L150 K151 G154 Y157 I183 R187 F191 L193 A194 N216 Y218 Y252 Y256 K259 H289 Q290 L293 K336 F339 V341 D345 D379
Binding residue
(residue number reindexed from 1)		R30 Q34 T40 W134 L137 K138 G141 Y144 I170 R174 F178 L180 A181 N203 Y205 Y239 Y243 K246 H276 Q277 L280 K313 F316 V318 D322 D356
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0009615 response to virus
GO:0019060 intracellular transport of viral protein in host cell
GO:0032091 negative regulation of protein binding
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051097 negative regulation of helicase activity
GO:0051607 defense response to virus
GO:0051707 response to other organism
GO:0071357 cellular response to type I interferon
GO:0071360 cellular response to exogenous dsRNA
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043657 host cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w5h, PDBe:5w5h, PDBj:5w5h
PDBsum5w5h
PubMed
UniProtP09914|IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (Gene Name=IFIT1)

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