Structure of PDB 5vo8 Chain C Binding Site BS01

Receptor Information
>5vo8 Chain C (length=1107) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRENVGIQAAFRE
TFPIEELVLDFLEYRLGEPPFPQDECREKDLTYQAPLYARLQLIHKDTGL
IKEDEVFLGHIPLMTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGR
YIASIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQETL
ARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGDPPKRDKAVAYV
YGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLARFEDGEFKDEVFLPTL
RYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRE
RMLMGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHK
RRISALGPGGLTRFDVRDVHRTHYGRICPVETPEGANIGLITSLAAYARV
DELGFIRTPYRRVVGGVVTDEVVYMTATEEDRYTIAQANTPLEGNRIAAE
RVVARRKGEPVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALMG
SNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKVDGNRI
VVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLADGPAS
ENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIERYEIE
ARDTKLGPERITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSF
KGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRLRRGDP
GVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNKGVVAKILPVEDMPHL
PDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQRYISPIFDGAKE
PEIKELLAQAFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPEE
QLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHARSTG
PYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKSDDIE
GRNAAYEAIIKGEDVPEPSVPESFRVLVKELQALALDVQTLDEKDNPVDI
FEGLASK
Ligand information
Receptor-Ligand Complex Structure
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PDB5vo8 X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R134 F394 G1023 K1024 R1031 M1035
Binding residue
(residue number reindexed from 1)		R127 F387 G1012 K1013 R1020 M1024
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vo8, PDBe:5vo8, PDBj:5vo8
PDBsum5vo8
PubMed28652344
UniProtQ8RQE9|RPOB_THET8 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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