Structure of PDB 5vi5 Chain C Binding Site BS01

Receptor Information
>5vi5 Chain C (length=1113) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLVGSDRWRQAAIDRGE
ENPVGGLEEVLAELSPIEDFSGSMSLSFSDPRFDEVKASVDECKDKDMTY
AAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQL
VRSPGVYFDETIDKSTEKTLHSVKVIPGRGAWLEFVRIDRKRRQPVTVLL
KALGWTNENIVERFGFSEIMMGTLEKDTTSGTDEALLDIYRKLRPGEPPT
KESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLNAGKPITSSTLTEEDV
VATIEYLVRLHEGQTSMTVPGGVEVPVEVDDIDHFGNRRLRTVGELIQNQ
IRVGLSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQ
FMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIET
PEGPNIGLIGSLSVYARVNPFGFIETPYRKVENGVVTDQIDYLTADEEDR
HVVAQANSPTDENGRFTEDRVMVRKKGGEVEFVSADQVDYMDVSPRQMVS
VATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDA
GDVVVADKTGVIEEVSADYITVMADDGTRQSYRLRKFARSNHGTCANQRP
IVDAGQRVEAGQVIADGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILS
NRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERG
IVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLK
VPHGESGKVIGIRVFSREDDDELPAGVNELVRVYVAQKRKISDGDKLAGR
HGNKGVIGKILPVEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGW
VAKAGWNIDVAAGVPDWASKLPEELYSAPADSTVATPVFDGAQEGELAGL
LGSTLPNRDGEVMVDADGKSTLFDGRSGEPFPYPVTVGYMYILKLHHLVD
DKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQEL
LTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVL
SSDGAAIEMRDGD
Ligand information
>5vi5 Chain O (length=49) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcttgacaaaagtgttaaattgtgctatactgggagccgtcacggatgc
Receptor-Ligand Complex Structure
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PDB5vi5 Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Resolution3.196 Å
Binding residue
(original residue number in PDB)		I196 W202 E457 R458 V463
Binding residue
(residue number reindexed from 1)		I176 W182 E428 R429 V434
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vi5, PDBe:5vi5, PDBj:5vi5
PDBsum5vi5
PubMed28703128
UniProtP60281|RPOB_MYCS2 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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