Structure of PDB 5uyx Chain C Binding Site BS01

Receptor Information
>5uyx Chain C (length=474) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEALKSHIMAAKAVANTMRTSLGPNGLNDGATILSMMDVDHQIAKLMVEL
SKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA
IEHLDKISDSVLVDIKDTEPLIQTAKSCHRQMAEIAVNAVLTVADMERRD
VDFELIKVEGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEP
PKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFD
DEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAG
LVQEISFGTTKDKMLVIEQAVTIFIRGGNKMIIEEAKRSLHDALCVIRNL
IRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMAL
SENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIG
KKQQISLATQMVRMILKIDDIRKP
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain5uyx Chain C Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5uyx Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		L52 G53 G105 T107 G422 C493 E508
Binding residue
(residue number reindexed from 1)		L22 G23 G61 T63 G360 C431 E446
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) D73 T106 T107 D404
Catalytic site (residue number reindexed from 1) D29 T62 T63 D342
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031681 G-protein beta-subunit binding
GO:0044183 protein folding chaperone
GO:0048027 mRNA 5'-UTR binding
GO:0048487 beta-tubulin binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0009615 response to virus
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uyx, PDBe:5uyx, PDBj:5uyx
PDBsum5uyx
PubMed28623285
UniProtP48643|TCPE_HUMAN T-complex protein 1 subunit epsilon (Gene Name=CCT5)

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