Structure of PDB 5uww Chain C Binding Site BS01

Receptor Information
>5uww Chain C (length=1005) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQ
KADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMII
SMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSV
NVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQ
VLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTR
AITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKA
TYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQ
LSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMV
RPEEDLVVVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDG
SEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDN
KAVVASDIMYVVGQYPRFLKAHWNFLRTVILALFEFMHETHEGVQDMACD
TFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKA
CGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVK
IIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEG
LIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLE
DYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINK
DFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNN
RDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSD
HKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLAN
MLSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPT
DYLFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5uww Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Resolution2.152 Å
Binding residue
(original residue number in PDB)		I532 N571 T575 F583
Binding residue
(residue number reindexed from 1)		I485 N524 T528 F536
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uww, PDBe:5uww, PDBj:5uww
PDBsum5uww
PubMed28282025
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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