Structure of PDB 5uws Chain C Binding Site BS01

Receptor Information
>5uws Chain C (length=997) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAW
QKADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMI
ISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSS
VNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF
QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDT
RAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLK
ATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLI
QLSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENM
VRPETIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNIN
TLSWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVASDIM
YVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKC
KYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEER
SVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTN
VAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKV
RGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDA
RDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHR
VEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQ
IALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQA
LLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHL
TSEQIASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFAE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5uws Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Resolution2.401 Å
Binding residue
(original residue number in PDB)		I532 K533 L536 K545 K548 M556 H569 F572 K579 F583 E586
Binding residue
(residue number reindexed from 1)		I476 K477 L480 K489 K492 M500 H513 F516 K523 F527 E530
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5uws, PDBe:5uws, PDBj:5uws
PDBsum5uws
PubMed28282025
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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