Structure of PDB 5uwi Chain C Binding Site BS01

Receptor Information
>5uwi Chain C (length=1001) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAW
QKADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMI
ISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSS
VNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF
QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDT
RAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLK
ATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLI
QLSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENM
VRPEKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSW
HNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVA
SDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKI
VQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIII
SEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANI
IKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATK
TPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNN
VPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEY
PEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEV
NGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGF
SKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNA
FPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFA
E
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5uwi Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Resolution2.143 Å
Binding residue
(original residue number in PDB)		K525 V529 L536 C539 K545 K548 H569 F572 T575 K579 F583 R616
Binding residue
(residue number reindexed from 1)		K473 V477 L484 C487 K493 K496 H517 F520 T523 K527 F531 R564
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5uwi, PDBe:5uwi, PDBj:5uwi
PDBsum5uwi
PubMed28282025
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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