Structure of PDB 5uw6 Chain C Binding Site BS01

Receptor Information

>5uw6 Chain C (length=701) Species: 39387 (Gypsophila vaccaria)

GFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEK
LANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQN
VFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTE
WVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPVNQEARY
HFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVY
CLDLTKLPNGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKK
LVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIR
DLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKN
DPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDG
SHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEW
HKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACI
NQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKY
SPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVL
CTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPW
I

Ligand information

>5uw6 Chain G (length=6) Species: 39387 (Gypsophila vaccaria)

NASAPV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5uw6 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): R81 F95 A102 N104 F492 S493 A494 S495 T700 Q703
• Binding residue (residue number reindexed from 1): R77 F91 A98 N100 F470 S471 A472 S473 T678 Q681

Enzymatic activity

• Catalytic site (original residue number in PDB): Y481 S562 D653 H695
• Catalytic site (residue number reindexed from 1): Y459 S540 D631 H673
• Enzyme Commision number: 3.4.21.-
  3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5uw6, PDBe:5uw6, PDBj:5uw6
• PDBsum: 5uw6
• PubMed: 28584123
• UniProt: R4P353