Structure of PDB 5tf6 Chain C Binding Site BS01

Receptor Information
>5tf6 Chain C (length=366) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTRNRELTTVLVKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRF
ARIEFARYDGALAAITKTHKVVGQNEIIVSHLTECTLWMTNFPPSYTQRN
IRDLLQDINVVALSIRLPSLRFNTSRRFAYIDVTSKEDARYCVEKLNGLK
IEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLSTELLDENLLRESFE
GFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSLLGNREI
SVSLADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFL
QEEIHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVI
RSGTINDMKRYYNNQQ
Ligand information
>5tf6 Chain B (length=71) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaauuugaaacaauacagagaugaucagcaguuccccugcauaagga
ugaaccguuuuacaaagagac
.<<<..<<<<...................<<<.<<<<.<<<.....>>>.
.>>>>.>>>...>>>>..>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tf6 Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K62 H63 Y90 K102
Binding residue
(residue number reindexed from 1)		K30 H31 Y58 K70
Binding affinityPDBbind-CN: Kd=2.9nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:5tf6, PDBe:5tf6, PDBj:5tf6
PDBsum5tf6
PubMed28045380
UniProtP49960|PRP24_YEAST U4/U6 snRNA-associated-splicing factor PRP24 (Gene Name=PRP24)

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