Structure of PDB 5oxf Chain C Binding Site BS01

Receptor Information
>5oxf Chain C (length=601) Species: 197 (Campylobacter jejuni) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMQINLLNDFIKAYENTYSVSFDDSFKGRIQELCKELNEPFMHASYAL
ENELKELVFSLDKNVNIAIIGQFSSGKSSLLNLILGRDCLPVPVTFKPTF
LRYAKEYFLRVEFEDGSDIITNIEKLAFYTDQRNEVKQAKSLHIFAPIPL
LEKITLVDTPGLNANENDTLTTLDELKNIHGAIWLSLIDNAGKKSEEDAI
KANLELLGENSICVLNQKDKLELDNVLNYAKSVFLKYFNELIAISCKEAK
DEQSYEKSNFQSLLDFLTQLDTTVLKEKFVKRKILNLCEILEDENQLFVG
IFDRLLNQFQSYEKHLLLAYENFLKEIEILNHQILEQLKSISERISSEIF
ASVKEKDAYFYKESKGFLKKDLYTRYDYKAPYISSDDAFLAMFYNSDVMS
KEFKKIKNELYKSFEEIKMKLKDFINILEREILLFKAEFSNIQKDHIFQS
DKNFSELRAFCNASDEYFLKDFKELLFKSILELDLFFEKLNLKAFTNYEN
ATKLSLAFFSRKINESRVLYELDYPKKSEIYERVLNELNVYEFETLLINK
PILTKIAKNFLEQSQNLIQEKNKFLDLKKAELQKRRAQILNVRESIKEDH
H
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain5oxf Chain C Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5oxf Structural basis for membrane tethering by a bacterial dynamin-like pair.
Resolution3.94 Å
Binding residue
(original residue number in PDB)		S71 G73 K74 S75 S76 P88 Q217 D219
Binding residue
(residue number reindexed from 1)		S74 G76 K77 S78 S79 P91 Q217 D219
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5oxf, PDBe:5oxf, PDBj:5oxf
PDBsum5oxf
PubMed30131557
UniProtA0A0H3PJK4|DLP2_CAMJJ Dynamin-like protein 2 (Gene Name=dlp2)

[Back to BioLiP]