Structure of PDB 5onb Chain C Binding Site BS01

Receptor Information
>5onb Chain C (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALL
QEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPL
FLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLC
LRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMV
LQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLK
DDTTTKRWLAQLVKNLQE
Ligand information
>5onb Chain D (length=22) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DDQQLDHNFKQMEEHLALMVEG
Receptor-Ligand Complex Structure
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PDB5onb DrosophilaBag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H85 N88 R130 E133 Y134 L137 G141 G144 V181 F184 K230 H231
Binding residue
(residue number reindexed from 1)		H68 N71 R113 E116 Y117 L120 G124 G127 V164 F167 K213 H214
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5onb, PDBe:5onb, PDBj:5onb
PDBsum5onb
PubMed29255063
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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