Structure of PDB 5ohn Chain C Binding Site BS01

Receptor Information
>5ohn Chain C (length=297) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRQYLSLTLL
HLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITS
SLEDERDHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAGH
PLTLDHCLHHFISSESVRDVVCDNCTKRTTFVKQLKLGKLPQCLCIHLQR
LSWSSHGTPLKRHEHVQFNEDLDMDEYKYHSNASTYLFRLMAVVVHHGDM
HSGHFVTYRRSPPSSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5ohn Chain C Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ohn Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C234 C237 C287
Binding residue
(residue number reindexed from 1)		C125 C128 C175
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) N72 C77
Catalytic site (residue number reindexed from 1) N9 C14
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5ohn, PDBe:5ohn, PDBj:5ohn
PDBsum5ohn
PubMed28945249
UniProtQ70CQ3|UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (Gene Name=USP30)

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