Structure of PDB 5o3w Chain C Binding Site BS01

Receptor Information

>5o3w Chain C (length=716) Species: 39387 (Gypsophila vaccaria)

FSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKL
ANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNV
FQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEW
VTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPLKEGEDHM
TRSAVNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYI
LDGCDDANKVYCLDLTKLPNGLESFRGSAPFMKLIDSFDASYTAIANDGS
VFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLI
LRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTS
ILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKI
PIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFC
LANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAI
EGGANGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYG
CSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVP
LHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVA
DRYGFMAKALEAPWID

Ligand information

>5o3w Chain Y (length=6) Species: 39387 (Gypsophila vaccaria)

NASAPV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5o3w Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): R81 F95 A102 N104 S493 A494 S495 T700 V707
• Binding residue (residue number reindexed from 1): R76 F90 A97 N99 S485 A486 S487 T692 V699

Enzymatic activity

• Enzyme Commision number: 3.4.21.-
  3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5o3w, PDBe:5o3w, PDBj:5o3w
• PDBsum: 5o3w
• PubMed: 29377663
• UniProt: R4P353