Structure of PDB 5njc Chain C Binding Site BS01

Receptor Information

>5njc Chain C (length=480) Species: 511145 (Escherichia coli str. K-12 substr. MG1655)

SLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLE
DRIIKDGSYNIDQGVGVRAISGEKTGFAYADQISLLALEQSAQAARTIVR
DSGDGKVQTLGAVEHSPLYTSVDPLQSMSREEKLDILRRVDKVAREADKR
VQEVTASLSGVYELILVAATDGTLAADVRPLVRLSVSVLVEEDGKRERGA
SGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSAVAAPAGTMPVV
LGAGWPGVLLHAAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDGT
MVDRRGSVAIDDEGTPGQYNVLIENGILKGYMQDKLNARLMGMTPTGNGR
RESYAHLPMPRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITSD
KFVFSTSEAYLIENGKVTKPVKGATLIGSGIETMQQISMVGNDLKLDNGV
GVCGKEGQSLPVGVGQPTLKVDNLTVGGTA

Ligand information

>5njc Chain F (length=6) Species: 511145 (Escherichia coli str. K-12 substr. MG1655)

VLEDRI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5njc The Origins of Specificity in the Microcin-Processing Protease TldD/E.
• Resolution: 1.35 Å
• Binding residue (original residue number in PDB): R184 H262 G393 G394 Q395 V396 V451 V453 C454 G455 K456
• Binding residue (residue number reindexed from 1): R183 H261 G392 G393 Q394 V395 V450 V452 C453 G454 K455

Enzymatic activity

• Enzyme Commision number: 3.4.-.-

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005515 protein binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0016485 protein processing

Cellular Component

• GO:0005829 cytosol
• GO:1905368 peptidase complex

External links

• PDB: RCSB:5njc, PDBe:5njc, PDBj:5njc
• PDBsum: 5njc
• PubMed: 28943336
• UniProt: P0AGG8|TLDD_ECOLI Metalloprotease TldD (Gene Name=tldD)