Structure of PDB 5n6n Chain C Binding Site BS01

Receptor Information
>5n6n Chain C (length=698) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPFSNAEVYYGNRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQ
GNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYK
HINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQ
FWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQAS
QMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLI
GYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYG
KILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASI
KEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPFKQLYN
DGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYE
IDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESG
FFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGG
LAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRL
AYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAAT
EGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain5n6n Chain D Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5n6n Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		P299 W309 D310 G476 D478 W624 W708
Binding residue
(residue number reindexed from 1)		P257 W267 D268 G423 D425 W571 W655
Annotation score5
Enzymatic activity
Enzyme Commision number 3.2.1.28: alpha,alpha-trehalase.
Gene Ontology
Molecular Function
GO:0004555 alpha,alpha-trehalase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015927 trehalase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0071465 cellular response to desiccation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n6n, PDBe:5n6n, PDBj:5n6n
PDBsum5n6n
PubMed29087344
UniProtP32356|TREA_YEAST Cytosolic neutral trehalase (Gene Name=NTH1)

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