Structure of PDB 5n6i Chain C Binding Site BS01
Receptor Information
>5n6i Chain C (length=357) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
Ligand information
>5n6i Chain G (length=37) [
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gatctactagtgatctatgactgatctgtacatgatc
Receptor-Ligand Complex Structure
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PDB
5n6i
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Resolution
3.6 Å
Binding residue
(original residue number in PDB)
P243 T334 K335 T338
Binding residue
(residue number reindexed from 1)
P95 T186 K187 T190
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:5n6i
,
PDBe:5n6i
,
PDBj:5n6i
PDBsum
5n6i
PubMed
28902841
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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