Structure of PDB 5m3h Chain C Binding Site BS01

Receptor Information

>5m3h Chain C (length=730) Species: 11320 (Influenza A virus)

SGMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMK
WMMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTW
WNRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDIN
PGHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKI
SPIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPGG
EAENDDLDQTLIIASRNIVRRSIVAIDPLASLLSMCHTTSISSEPLVEIL
RSNPTDEQAVNICKAALGIRINNSFSFGGYNFKRVKGSSQRTEKAVLTGN
LQTLTMTIFEGYEEFNVSGKRASAVLKKGAQRLIQAIIGGRTLEDILNLM
ITLMVFSQEEKMLKAVRGDLNFVNQRLNPMYQLLRHFQKDSSTLLKNWGT
EEIDPIMGIAGIMPDGTINKTQTLMGVRLSQIRVNIDKYLRVRNEKGELL
ISPEEVSEAQGQEKLPINYNSSLMWEVNGPESILTNTYHWIIKNWELLKT
QWMTDPTVLYNRIEFEPFQTLIPKGNRAIYSGFTRTLFQQMRDVEGTFDS
IQIIKLLPFSAHPPSLGRTQFSSFTLNIRGAPLRLLIRGNSQVFNYNQME
NVIIVLGKSVGSPERSILTESSSIESAVLRGFLILGKANSKYGPVLTIGE
LDKLGRGEKANVLIGQGDTVLVMKRKRDSS

Ligand information

>5m3h Chain R (length=13)

uauaccucugcuu

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5m3h Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): S36 G37 R38 E40 R46 W49
• Binding residue (residue number reindexed from 1): S38 G39 R40 E42 R48 W51

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:5m3h, PDBe:5m3h, PDBj:5m3h
• PDBsum: 5m3h
• PubMed: 28002402
• UniProt: H6QM90