Structure of PDB 5ly1 Chain C Binding Site BS01
Receptor Information
>5ly1 Chain C (length=342) Species:
9606
(Homo sapiens) [
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SETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWK
PRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSD
KYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLR
TILDLVEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVP
PEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQ
EAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDM
VKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>5ly1 Chain E (length=13) Species:
32630
(synthetic construct) [
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YVYNTRSGWRWYT
Receptor-Ligand Complex Structure
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PDB
5ly1
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
A69 N86 I87 Q88 D135 Y175 Y177 H240 K241 S288 T289 C308 R309 D311
Binding residue
(residue number reindexed from 1)
A65 N82 I83 Q84 D131 Y163 Y165 H228 K229 S276 T277 C296 R297 D299
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G158 Y165 H176 E178 H264 S276
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:5ly1
,
PDBe:5ly1
,
PDBj:5ly1
PDBsum
5ly1
PubMed
28382930
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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