Structure of PDB 5lpn Chain C Binding Site BS01

Receptor Information
>5lpn Chain C (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQG
KKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLR
NIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIETSAKANIN
IEKAFLTLAEDILRKTP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5lpn Chain C Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lpn bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T23 T41
Binding residue
(residue number reindexed from 1)		T18 T36
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Q68
Catalytic site (residue number reindexed from 1) Q63
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5lpn, PDBe:5lpn, PDBj:5lpn
PDBsum5lpn
PubMed27552051
UniProtP61026|RAB10_HUMAN Ras-related protein Rab-10 (Gene Name=RAB10)

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