Structure of PDB 5lhd Chain C Binding Site BS01

Receptor Information
>5lhd Chain C (length=905) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFT
CKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYL
VVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQM
QAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDP
NWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAG
HGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTY
RENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEG
FASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEI
NTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNT
IYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLS
QEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLF
STSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQII
NDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRS
EVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACS
NGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFA
WEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATST
IISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTE
YELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWF
TENSK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lhd Chain C Residue 1134 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lhd Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H388 H392 E411
Binding residue
(residue number reindexed from 1)		H326 H330 E349
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E355 H388 E389 H392 E411 S469 Y477
Catalytic site (residue number reindexed from 1) E293 H326 E327 H330 E349 S407 Y415
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0038023 signaling receptor activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0043171 peptide catabolic process
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0030667 secretory granule membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lhd, PDBe:5lhd, PDBj:5lhd
PDBsum5lhd
PubMed28393915
UniProtP15144|AMPN_HUMAN Aminopeptidase N (Gene Name=ANPEP)

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