Structure of PDB 5kor Chain C Binding Site BS01

Receptor Information

>5kor Chain C (length=449) Species: 3702 (Arabidopsis thaliana)

SDKLLGGLLASGFDEDSCLSRYQSVHYRKPSPYKPSSYLISKLRNYEKLH
KRCGPGTESYKKALKQLDQEHIDGDGECKYVVWISFSGLGNRILSLASVF
LYALLTDRVLLVDRGKDMDDLFCEPFLGMSWLLPLDFPMTDQFDGLNQES
SRCYGYMVKNQVIGTLSHLYLHLVHDYGDHDKMFFCEGDQTFIGKVPWLI
VKTDNYFVPSLWLIPGFDDELNKLFPQKATVFHHLGRYLFHPTNQVWGLV
TRYYEAYLSHADEKIGIQVRVFDEDPGPFQHVMDQISSCTQKEKLLPEVD
TLVTPKHKAVLVTSLNAGYAENLKSMYWEYPTSTGEIIGVHQPSQEGKMH
NGKALAEMYLLSLTDNLVTSAWSTFGYVAQGLGGLKPWILYRPENRTTPD
PSCGRAMSMEPCFHSPPFYDCKAKTGIDTGTLVPHVRHCEDISWGLKLV

Ligand information

• Ligand ID: XYS
• InChI: InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3+,4-,5+/m1/s1
• InChIKey: SRBFZHDQGSBBOR-LECHCGJUSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C1C(C(C(C(O1)O)O)O)O
  CACTVS 3.341: O[CH]1CO[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O
  CACTVS 3.341: O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O
  ACDLabs 10.04: OC1C(O)COC(O)C1O
• Formula: C5 H10 O5
• Name: alpha-D-xylopyranose;
  alpha-D-xylose;
  D-xylose;
  xylose;
  XYLOPYRANOSE
• DrugBank: DB03389
• ZINC: ZINC000001529214
• PDB chain: 5kor Chain F Residue 5

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5kor Structure of Arabidopsis thaliana FUT1 Reveals a Variant of the GT-B Class Fold and Provides Insight into Xyloglucan Fucosylation.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): K278 S524 P525
• Binding residue (residue number reindexed from 1): K182 S415 P416
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.1.-

Gene Ontology

Molecular Function

• GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity

Biological Process

• GO:0042546 cell wall biogenesis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5kor, PDBe:5kor, PDBj:5kor
• PDBsum: 5kor
• PubMed: 27637560
• UniProt: Q9SWH5|FUT1_ARATH Galactoside 2-alpha-L-fucosyltransferase (Gene Name=FUT1)