Structure of PDB 5is6 Chain C Binding Site BS01

Receptor Information
>5is6 Chain C (length=342) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFK
DKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDR
IVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGN
MFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY
FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLV
HGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTL
SGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY
Ligand information
Ligand IDDXE
InChIInChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
InChIKeyXTHFKEDIFFGKHM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O(C)CCOC
CACTVS 3.341
OpenEye OEToolkits 1.5.0		COCCOC
FormulaC4 H10 O2
Name1,2-DIMETHOXYETHANE
ChEMBLCHEMBL1232411
DrugBankDB01749
ZINCZINC000001690289
PDB chain5is6 Chain C Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5is6 Crystal structure of mouse CARM1 in complex with Sinefungin at 2.0 Angstroms resolution
Resolution2.007 Å
Binding residue
(original residue number in PDB)		F336 Q424
Binding residue
(residue number reindexed from 1)		F201 Q289
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D166 E258 E267 H415
Catalytic site (residue number reindexed from 1) D31 E123 E132 H280
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5is6, PDBe:5is6, PDBj:5is6
PDBsum5is6
PubMed
UniProtQ9WVG6|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)

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