Structure of PDB 5huk Chain C Binding Site BS01

Receptor Information

>5huk Chain C (length=388) Species: 1589662 (Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2)))

AEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCSPGKCYQ
FALGQGTTLNNKHSNGTIHDRIPHRTLLMSELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCVTGDDRNATASFIYDGMLADSIGSWSQNILRTQESECV
CINGTCTVVMTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCY
PRYPDVRCVCRDNWKGSNRPVIDINMADYSIDSSYVCSGLVGDTPRNDDS
SSSSNCRDPNNERGNPGVKGWAFDNGNDVWMGRTISEDSRSGYETFRVTD
GWTTANSKSQVNRQIIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRP
QETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5huk Chain C Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5huk Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): D293 G297 S298 D324 G345 G348
• Binding residue (residue number reindexed from 1): D212 G216 S217 D243 G264 G267
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D151 E277 R292 R371 Y406
• Catalytic site (residue number reindexed from 1): D70 E196 R211 R290 Y325
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:5huk, PDBe:5huk, PDBj:5huk
• PDBsum: 5huk
• PubMed: 27053557
• UniProt: A0A0C4WXC5