Structure of PDB 5hro Chain C Binding Site BS01 |
| >5hro Chain C (length=551) Species: 11678 (Human immunodeficiency virus type 1 BH10)
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PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPE
NPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKK
KSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGW
KGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIE
ELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWT
VNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELEL
AENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGK
YARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWT
EYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLG
KAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYAL
GIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVS
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| PDB | 5hro Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. |
| Resolution | 2.75 Å |
Binding residue
(original residue number in PDB) | W24 F61 L74 D76 R78 E89 Q91 I94 G152 W153 K154 P157 Y183 D185 D186 M230 G231 N255 Q258 G262 K263 W266 S280 R284 G285 L289 K353 G359 H361 R448 T473 Q475 K476 Y501 |
Binding residue
(residue number reindexed from 1) | W21 F58 L71 D73 R75 E86 Q88 I91 G149 W150 K151 P154 Y180 D182 D183 M227 G228 N252 Q255 G259 K260 W263 S277 R281 G282 L286 K350 G356 H358 R445 T470 Q472 K473 Y498 |
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