Structure of PDB 5h8l Chain C Binding Site BS01

Receptor Information
>5h8l Chain C (length=301) Species: 3880 (Medicago truncatula) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAEDKGRKVVVSALQFACTDDVSTNVTTAERLVRAAHKQGANIVLIQELF
EGYYFCQAQREDFIQRAKPYKDHPTIMRLQKLAKELGVVIPVSFFEEANN
AHYNSIAIIDADGTDLGIYRKSHIPDGPGYEEKFYFNPGDTGFKVFQTKY
AKIGVAISWDQWFPEAARAMALQGAEILFYPTAIGSEPHDQSIDSRDHWK
RVMQGHAGANLVPLVASNRIGNEIIETEHGKSEIKFYGNSFIAGPTGEIV
SIADDKEEAVLIAEFNLDKIKSMRHCWGVFRDRRPDLYKVLLTLDGKNPV
L
Ligand information
Ligand IDPUT
InChIInChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
InChIKeyKIDHWZJUCRJVML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CCN)CN
ACDLabs 10.04
CACTVS 3.341		NCCCCN
FormulaC4 H12 N2
Name1,4-DIAMINOBUTANE;
PUTRESCINE
ChEMBLCHEMBL46257
DrugBankDB01917
ZINCZINC000005828633
PDB chain5h8l Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5h8l Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		Y130 E187
Binding residue
(residue number reindexed from 1)		Y130 E187
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) E48 N104 K121 E132 S158 A183
Catalytic site (residue number reindexed from 1) E48 N104 K121 E132 S158 A183
Enzyme Commision number 3.5.1.53: N-carbamoylputrescine amidase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0050126 N-carbamoylputrescine amidase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0033388 putrescine biosynthetic process from arginine

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5h8l, PDBe:5h8l, PDBj:5h8l
PDBsum5h8l
PubMed27066023
UniProtG7ITU5

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