Structure of PDB 5f9f Chain C Binding Site BS01 |
| >5f9f Chain C (length=668) Species: 9606 (Homo sapiens)
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FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQK
GKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVEN
NDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNY
LDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDEFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYND
ALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGN
PKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVA
DEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEK
EQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPVPDKE
NKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFS
SFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTL
YSKWKDFHFEKIPFDPAE |
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| PDB | 5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. |
| Resolution | 2.601 Å |
Binding residue
(original residue number in PDB) | N298 I300 S325 G326 T347 Q349 K379 Q380 Q507 E510 K518 R546 K635 T636 R637 T662 G663 R664 T667 N668 T697 S698 N720 K750 H830 F853 K858 I875 V886 K888 W908 K909 |
Binding residue
(residue number reindexed from 1) | N58 I60 S85 G86 T107 Q109 K139 Q140 Q257 E260 K268 R296 K385 T386 R387 T412 G413 R414 T417 N418 T447 S448 N470 K500 H576 F599 K604 I621 V632 K634 W654 K655 |
| Binding affinity | PDBbind-CN: Kd=38.5nM |
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| Enzyme Commision number |
3.6.4.13: RNA helicase. |
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