Structure of PDB 5f0l Chain C Binding Site BS01

Receptor Information
>5f0l Chain C (length=155) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRV
KTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPF
RGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKS
YTPSK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f0l Structural Mechanism for Cargo Recognition by the Retromer Complex.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		V88 H132
Binding residue
(residue number reindexed from 1)		V85 H129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0019903 protein phosphatase binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:1901981 phosphatidylinositol phosphate binding
GO:1905394 retromer complex binding
Biological Process
GO:0009617 response to bacterium
GO:0010324 membrane invagination
GO:0010976 positive regulation of neuron projection development
GO:0015031 protein transport
GO:0022615 protein to membrane docking
GO:0030111 regulation of Wnt signaling pathway
GO:0032456 endocytic recycling
GO:0034499 late endosome to Golgi transport
GO:0042177 negative regulation of protein catabolic process
GO:0046597 negative regulation of viral entry into host cell
GO:0050765 negative regulation of phagocytosis
GO:0051224 negative regulation of protein transport
GO:0070676 intralumenal vesicle formation
GO:2000642 negative regulation of early endosome to late endosome transport
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0030136 clathrin-coated vesicle
GO:0030904 retromer complex
GO:0031901 early endosome membrane
GO:0032009 early phagosome
GO:0045335 phagocytic vesicle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f0l, PDBe:5f0l, PDBj:5f0l
PDBsum5f0l
PubMed27889239
UniProtO60493|SNX3_HUMAN Sorting nexin-3 (Gene Name=SNX3)

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