Structure of PDB 5exr Chain C Binding Site BS01

Receptor Information
>5exr Chain C (length=1057) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKAEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKGERNATCGRMICDVE
ISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEH
TWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLH
AFYENNYIVPDKQIGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFT
TVQRVIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQY
DIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQ
KMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDG
VFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTG
NFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKD
PQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRA
YAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLD
PTQFRVHHYHKDEENDQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGS
GTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICE
EPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIF
DAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEV
NLSKLFA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5exr Chain C Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5exr Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C1283 C1286 C1310 C1315
Binding residue
(residue number reindexed from 1)		C884 C887 C911 C916
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:1902975 mitotic DNA replication initiation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5exr, PDBe:5exr, PDBj:5exr
PDBsum5exr
PubMed26975377
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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