Structure of PDB 5e25 Chain C Binding Site BS01
Receptor Information
>5e25 Chain C (length=285) Species:
565033
(Geoglobus acetivorans) [
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SELLVYMNGEFVPESQAKVSVFDHGFLYGDGVFEGIRAYNGKVFKLYEHI
DRLYDCARVIDLKIPLSKEEFAEAILETLRRNNLRDAYIRPIVTRGAGDL
GLDPRKCPSPNVIIITKPWLYEKGLKAITVAIRRNAIDSLPPNIKSLNYL
NNILAKIEANAKGGDEAIFLDHNGYISEGSGDNIFIVKNGTITTPPTLNN
LKGITRQVVIELINELEIPFREANIGLFDLYSADEIFVTGTAAEIAPVTY
IDGRTVGNGKPGKVTKMLMEKFRERTENEGVEIYR
Ligand information
Ligand ID
PLP
InChI
InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKey
NGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0
Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04
O=P(O)(O)OCc1cnc(c(O)c1C=O)C
Formula
C8 H10 N O6 P
Name
PYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBL
CHEMBL82202
DrugBank
DB00114
ZINC
ZINC000001532514
PDB chain
5e25 Chain C Residue 301 [
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Receptor-Ligand Complex Structure
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PDB
5e25
Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus : Biochemical and Structural Characterization.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
R53 K152 Y156 E185 G188 D189 L208 I211 T212 T248
Binding residue
(residue number reindexed from 1)
R52 K145 Y149 E178 G181 D182 L201 I204 T205 T241
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
F34 G36 K152 E185 L208
Catalytic site (residue number reindexed from 1)
F33 G35 K145 E178 L201
Enzyme Commision number
2.6.1.42
: branched-chain-amino-acid transaminase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0004084
branched-chain-amino-acid transaminase activity
GO:0008483
transaminase activity
GO:0052654
L-leucine-2-oxoglutarate transaminase activity
GO:0052655
L-valine-2-oxoglutarate transaminase activity
GO:0052656
L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652
amino acid biosynthetic process
GO:0009081
branched-chain amino acid metabolic process
GO:0009082
branched-chain amino acid biosynthetic process
GO:0009097
isoleucine biosynthetic process
GO:0009098
L-leucine biosynthetic process
GO:0009099
L-valine biosynthetic process
GO:0019752
carboxylic acid metabolic process
GO:0046394
carboxylic acid biosynthetic process
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Molecular Function
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Biological Process
External links
PDB
RCSB:5e25
,
PDBe:5e25
,
PDBj:5e25
PDBsum
5e25
PubMed
30733943
UniProt
A0A0A7GJ30
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