Structure of PDB 5d8n Chain C Binding Site BS01

Receptor Information
>5d8n Chain C (length=504) Species: 4081 (Solanum lycopersicum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGDTLGLTRPNESDAPKISIGAKDTAVVQWQGDLLAIGATENDMARDENS
KFKNPLLQQLDSELNGLLSAASSEEDFSGKSGQSVNLRFPGGRITLVGLG
SSASSPTSYHSLGQAAAAAAKSSQARNIAVALASTDGLSAESKINSASAI
ATGVVLGSFEDNRFRSESKKSTLESLDILGLGTGPEIERKIKYAEHVCAG
VILGRELVNAPANIVTPAVLAEEAKKIASTYSDVISVNILDAEQCKELKM
GAYLAVAAAATENPPYFIHLCFKTPTKERKTKLALVGKGLTFDSGLMKND
MGGAAAVLGAAKALGEIRPSRVEVHFIVAACENMISAEGMRPGDIVTASN
GKTIEVNNTDAEGRLTLADALIYACNQGVEKIIDLATLTGAIMVALGPSV
AGAFTPNDDLAREVVEAAEASGEKLWRMPMEESYWESMKSGVADMINTGP
GNGGAITGALFLKQFVDEKVQWLHLDVAGPVWSDEKKNATGYGVSTLVEW
VLRN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5d8n Chain C Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5d8n Structural insights into chaperone-activity enhancement by a K354E mutation in tomato acidic leucine aminopeptidase.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		V262 A264
Binding residue
(residue number reindexed from 1)		V208 A210
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) R431
Catalytic site (residue number reindexed from 1) R364
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.5: prolyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0009611 response to wounding
GO:0009617 response to bacterium
GO:0009625 response to insect
GO:0019538 protein metabolic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005737 cytoplasm
GO:0009507 chloroplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5d8n, PDBe:5d8n, PDBj:5d8n
PDBsum5d8n
PubMed27139632
UniProtQ10712|AMPL1_SOLLC Leucine aminopeptidase 1, chloroplastic (Gene Name=LAPA1)

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