Structure of PDB 5d5k Chain C Binding Site BS01

Receptor Information
>5d5k Chain C (length=424) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIP
KFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA
SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLA
CGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSC
WAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT
GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQ
VVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGII
EPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK
IEALQRHENESVYKASLNLIEKYF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5d5k PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S105 R106 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 D280 V321 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		S33 R34 W70 N74 S77 G78 T83 Q109 W112 N116 G119 D120 W159 R166 W201 D208 V249 W285 N289 E324 W327
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5d5k, PDBe:5d5k, PDBj:5d5k
PDBsum5d5k
PubMed26704974
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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