Structure of PDB 5d39 Chain C Binding Site BS01

Receptor Information
>5d39 Chain C (length=484) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QEELKFKTGLRRLQHRVGEIHLLREALEALAMLLQETTGELEAAKALVLK
RIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGEL
EPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGL
RFPAKPPLVRADMVTEKQARELESTGEIINNTVPLENSIPGNCCSALFKN
LLLKKIKRCETESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVH
GNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGT
NRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFW
QWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSD
SEIGGITIAHVIRGGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYP
KKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5d39 Structural basis for DNA recognition by STAT6
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K284 K288 H415
Binding residue
(residue number reindexed from 1)		K135 K139 H250
Binding affinityPDBbind-CN: Kd=1.8uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5d39, PDBe:5d39, PDBj:5d39
PDBsum5d39
PubMed27803324
UniProtP42226|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

[Back to BioLiP]