Structure of PDB 5cw3 Chain C Binding Site BS01

Receptor Information
>5cw3 Chain C (length=239) Species: 104421 (Camponotus floridanus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQKVELQTDVYMVCLQHALSTENFEVMGLLIGNFACGIAKISAVIILRRD
KKKDSSEQLLKAAAEAERLTVELNRPMRVLGWYHSHPHITVCPSHVDVRT
QATYQTMDHSFVGLIFSVFSEGKESKEHEIFLNCFQSDNEATEIPLEIVH
TPDISDRCLRTMTDLSKILVQEEEDMAEACKDHPDVLASIHNNAVRTRAL
IHITDIITKPLVQTFEKRIALNKLRATHLQRQLQELQKM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5cw3 Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cw3 Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		H94 H96 D107
Binding residue
(residue number reindexed from 1)		H84 H86 D97
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.-
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0046872 metal ion binding
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006508 proteolysis
GO:0051301 cell division
GO:0070536 protein K63-linked deubiquitination
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cw3, PDBe:5cw3, PDBj:5cw3
PDBsum5cw3
PubMed26344097
UniProtE2AXC7|BRCC3_CAMFO Lys-63-specific deubiquitinase BRCC36 (Gene Name=BRCC3)

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