Structure of PDB 5btr Chain C Binding Site BS01

Receptor Information

>5btr Chain C (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPP
PELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGY
ARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFI
ALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDC
EAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVI
GSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINEL
CHRLGGEYAKLSFLPPNRYIFH

Ligand information

>5btr Chain D (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RHKA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5btr Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
Resolution	3.2 Å
Binding residue (original residue number in PDB)	F148 D150 P180
Binding residue (residue number reindexed from 1)	F5 D7 P18

Enzymatic activity

Catalytic site (original residue number in PDB)	N346 D348 H363
Catalytic site (residue number reindexed from 1)	N166 D168 H183
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase.

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

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Molecular Function

External links

PDB	RCSB:5btr, PDBe:5btr, PDBj:5btr
PDBsum	5btr
PubMed	26109052
UniProt	Q96EB6\|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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