Structure of PDB 5btl Chain C Binding Site BS01

Receptor Information
>5btl Chain C (length=487) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGF
RPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQG
NFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPT
VLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEE
TLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSR
GRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRI
VIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRY
YVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETV
DIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIAD
LEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5btl Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y28 R128 Y129 I181 A182 G184 M185
Binding residue
(residue number reindexed from 1)		Y14 R114 Y115 I167 A168 G170 M171
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5btl, PDBe:5btl, PDBj:5btl
PDBsum5btl
PubMed26792525
UniProtP9WG47|GYRA_MYCTU DNA gyrase subunit A (Gene Name=gyrA)

[Back to BioLiP]