Structure of PDB 5b4w Chain C Binding Site BS01

Receptor Information
>5b4w Chain C (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQAGEPLLFVGRGYTSRGI
PPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFL
FLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAV
ATSREVAHGEVLFAAFSSAAPRPPSAAAASALCAFPLDEVDRLANRTRDA
CYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASR
VPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDG
HPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVAS
Ligand information
Receptor-Ligand Complex Structure
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PDB5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
Resolution2.6 Å
Binding residue
(original residue number in PDB)		F294 P325 T395 P396 I397 E399 D414 G415 H416 T417 L433 G434 S437
Binding residue
(residue number reindexed from 1)		F263 P286 T356 P357 I358 E360 D375 G376 H377 T378 L394 G395 S398
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum5b4w
PubMed27984026
UniProtO43157|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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