Structure of PDB 4zrk Chain C Binding Site BS01

Receptor Information
>4zrk Chain C (length=295) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI
KDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLF
FLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL
LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD
KEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA
Ligand information
>4zrk Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PKFGTHHKALQEIRNSLLPFA
Receptor-Ligand Complex Structure
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PDB4zrk Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Resolution2.316 Å
Binding residue
(original residue number in PDB)		F35 N36 W41 D45 L49 R52 T53
Binding residue
(residue number reindexed from 1)		F17 N18 W23 D27 L31 R34 T35
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:4zrk, PDBe:4zrk, PDBj:4zrk
PDBsum4zrk
PubMed26045165
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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