Structure of PDB 4z2e Chain C Binding Site BS01

Receptor Information
>4z2e Chain C (length=197) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHMKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQ
AILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQK
LVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPGEMDDHQLW
ETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVY
Ligand information
Receptor-Ligand Complex Structure
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PDB4z2e Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.46 Å
Binding residue
(original residue number in PDB)		L460 N461 H513 R633
Binding residue
(residue number reindexed from 1)		L60 N61 H113 R187
Enzymatic activity
Catalytic site (original residue number in PDB) Y643
Catalytic site (residue number reindexed from 1) Y197
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4z2e, PDBe:4z2e, PDBj:4z2e
PDBsum4z2e
PubMed
UniProtP0A4M0|GYRB_STRR6 DNA gyrase subunit B (Gene Name=gyrB)

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