BioLiP

Receptor Information

>4yi0 Chain C (length=425) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIP
KFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA
SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLA
CGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSC
WAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT
GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQ
VVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGII
EPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK
IEALQRHENESVYKASLNLIEKYFS

>4yi0 Chain A (length=27) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EKKKRTVAEEDQLHLDGQENKRRRHDS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4yi0 Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane
Resolution	1.806 Å
Binding residue (original residue number in PDB)	R101 K102 L104 S105 R106 E107 P110 F138 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 R238 D270 W273 Y277 G281 R315 N319 V321 T322 E354 W357 N361 W399
Binding residue (residue number reindexed from 1)	R29 K30 L32 S33 R34 E35 P38 F66 W70 N74 S77 G78 T83 Q109 W112 N116 G119 D120 N156 W159 R166 D198 W201 Y205 G209 R243 N247 V249 T250 E282 W285 N289 W327

Enzyme Commision number

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

PDB	RCSB:4yi0, PDBe:4yi0, PDBj:4yi0
PDBsum	4yi0
PubMed
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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Structure of PDB 4yi0 Chain C Binding Site BS01