Structure of PDB 4wsb Chain C Binding Site BS01

Receptor Information

>4wsb Chain C (length=734) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMKW
MMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTWW
NRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDINP
GHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKIS
PIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPGGE
AENDDLDQTLIIASRNIVRRSIVAIDPLASLLSMCHTTSISSEPLVEILR
SNPTDEQAVNICKAALGIRINNSFSFGGYNFKRVKGSSQRTEKAVLTGNL
QTLTMTIFEGYEEFNVSGKRASAVLKKGAQRLIQAIIGGRTLEDILNLMI
TLMVFSQEEKMLKAVRGDLNFVNRANQRLNPMYQLLRHFQKDSSTLLKNW
GTEEIDPIMGIAGIMPDGTINKTQTLMGVRLSQNERIRVNIDKYLRVRNE
KGELLISPEEVSEAQGQEKLPINYNSSLMWEVNGPESILTNTYHWIIKNW
ELLKTQWMTDPTVLYNRIEFEPFQTLIPKGNRAIYSGFTRTLFQQMRDVE
GTFDSIQIIKLLPFSAHPPSLGRTQFSSFTLNIRGAPLRLLIRGNSQVFN
YNQMENVIIVLGKSVGSPERSILTESSSIESAVLRGFLILGKANSKYGPV
LTIGELDKLGRGEKANVLIGQGDTVLVMKRKRDS

Ligand information

>4wsb Chain R (length=13)

uauaccucugcuu

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4wsb Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): G37 R38 E40 R46 W49
• Binding residue (residue number reindexed from 1): G38 R39 E41 R47 W50

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:4wsb, PDBe:4wsb, PDBj:4wsb
• PDBsum: 4wsb
• PubMed: 25409151
• UniProt: H6QM90