Structure of PDB 4wsa Chain C Binding Site BS01

Receptor Information
>4wsa Chain C (length=730) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMK
WAMCSNFPLALTKGDMANRIPLEYKGIQLKTNAEDIGTKGQMCSIAAVTW
WNTYGPIGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLN
PLTKEMPPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMI
TPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGG
NKLTESRSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCL
AAIDGGDVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGN
GTIQKIGIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDLI
ILCMVFSQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFDQ
WGYEESPKASELHGINESMNASDYTLKGVVVTRNVKVSITKNLSLIKRTG
EVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLVT
LKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEVM
KTDQFIKLLPFCFSPPKLRSNGEPYQFLKLVLKGGGENFIEVRKGSPLFS
YNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLGD
FKTIEELEKLKPGEKANILLYQGKPVKVVK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4wsa Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		T38 R40 E42 R48 W51
Binding residue
(residue number reindexed from 1)		T38 R40 E42 R48 W51
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0033650 host cell mitochondrion
GO:0042025 host cell nucleus
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4wsa, PDBe:4wsa, PDBj:4wsa
PDBsum4wsa
PubMed25409151
UniProtQ5V8X3

[Back to BioLiP]