Structure of PDB 4ux9 Chain C Binding Site BS01

Receptor Information
>4ux9 Chain C (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNFYSVEIGDSTFTVLKRYQNLKPIGSGQGIVCAAYDAILERNVAIKKLS
RPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVM
ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLARTAGYVVTRYYRAPEVILGMGYKENVDLWSVGCIM
GEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPK
YAGYSFEKLFPDVLFPLKASQARDLLSKMLVIDASKRISVDEALQHPYIN
VWYDPSEAEAPPPKIPHTIEEWKELIYKEVMDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ux9 Structure and Dynamics of the Mkk7-Jnk Signaling Complex.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		Q117 M121 R127 Y130 K160 S161 C163 W324
Binding residue
(residue number reindexed from 1)		Q109 M113 R119 Y122 K152 S153 C155 W302
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161 T173
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ux9, PDBe:4ux9, PDBj:4ux9
PDBsum4ux9
PubMed25737554
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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