Structure of PDB 4ubf Chain C Binding Site BS01

Receptor Information
>4ubf Chain C (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEI
DVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFT
ARPLVQTIFEGGKATCFAYGQTGSGKTHTMGKGIYAMASRDVFLLKNQPC
YRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGQQVQVVGLQEHLVN
SADDVIKMIDMGSACRNSSRSHACFQIILRAKGRMHGKFSLVDLAGNEGA
EINKSLLALKECIRALGQNKATPFRESKLTQVLRDSFIGENSRTCMIATI
SPGISSCEYTLNTLRYADRVKE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4ubf Chain C Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ubf The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T355 R456
Binding residue
(residue number reindexed from 1)		T127 R216
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4ubf, PDBe:4ubf, PDBj:4ubf
PDBsum4ubf
PubMed25915621
UniProtQ99661|KIF2C_HUMAN Kinesin-like protein KIF2C (Gene Name=KIF2C)

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