Structure of PDB 4u7t Chain C Binding Site BS01

Receptor Information
>4u7t Chain C (length=418) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLE
CAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ
AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFAPKVYPPVPAEKRK
PIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIM
YVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFF
EFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDA
KEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRT
IQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWS
VPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4u7t Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D529 D531 Q534 Y536 G543 R544 E545 V546 L547 M548 A575 I576 E578 W581
Binding residue
(residue number reindexed from 1)		D56 D58 Q61 Y63 G70 R71 E72 V73 L74 M75 A102 I103 E105 W108
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:4u7t, PDBe:4u7t, PDBj:4u7t
PDBsum4u7t
PubMed25383530
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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