Structure of PDB 4rqe Chain C Binding Site BS01

Receptor Information
>4rqe Chain C (length=452) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRAD
NLNKLKNLCSKTIGEKMKENVLSFDADALANLKVSQIKKVRLLIDEAILK
CDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVTSIWGDCTVRK
KYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLG
SRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEK
YLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIF
RVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVS
GSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYMDKVEF
VHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVK
PA
Ligand information
>4rqe Chain D (length=83) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccggaugauccucaguggucuggggugcaggcuaaaccuguagcuguc
uagcgacagagugguucaauuccaccuuucggg
.....<<....<<<<<<....>>>>>>.<<<<<.....>>>>>..<<<<<
....>>>>>.<<<.........>>>..>>....
Receptor-Ligand Complex Structure
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PDB4rqe SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		R44 S61
Binding residue
(residue number reindexed from 1)		R43 S60
Enzymatic activity
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0060090 molecular adaptor activity
GO:0098619 selenocysteine-tRNA ligase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001514 selenocysteine incorporation
GO:0002181 cytoplasmic translation
GO:0006400 tRNA modification
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016525 negative regulation of angiogenesis
GO:1904046 negative regulation of vascular endothelial growth factor production
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rqe, PDBe:4rqe, PDBj:4rqe
PDBsum4rqe
PubMed26433229
UniProtP49591|SYSC_HUMAN Serine--tRNA ligase, cytoplasmic (Gene Name=SARS1)

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