Structure of PDB 4rhm Chain C Binding Site BS01

Receptor Information

>4rhm Chain C (length=302)

SHMFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQS
PRDCDHYAELTIHDKGPIECPPETVMFMPVLNCGQMLDTETPTSDEWYLG
SLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPSDDIVIVHFDAHP
DVSDPRSPLRVLLDKGLLKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAI
YSKGLFCIRDIRNDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHI
MNGIRGPKVVGIDVYGYNPDLDVYRKDNVGLTAIALSKIIKEGILKAYSI
ST

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4rhm Chain C Residue 404

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4rhm Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster.
• Resolution: 1.95 Å
• Binding residue (original residue number in PDB): D149 H151 D224 D226
• Binding residue (residue number reindexed from 1): D147 H149 D222 D224
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.3.1: arginase.

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0008783 agmatinase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006525 arginine metabolic process
• GO:0033389 putrescine biosynthetic process from arginine, using agmatinase

External links

• PDB: RCSB:4rhm, PDBe:4rhm, PDBj:4rhm
• PDBsum: 4rhm
• PubMed: 25536859
• UniProt: Q581Y0